沈锡辉
一、基本情况
沈锡辉，304永利集团官网入口304永利集团官网入口教授、博导，国家杰出青年科学基金获得者，入选国家“万人计划”、科技部中青年科技创新领军人才推进计划和陕西省特支计划，旱区作物逆境生物学国家重点实验室学术骨干，“农业与环境微生物学研究团队”学术带头人，304永利集团官网入口“青年英才培养计划”首届入选者。1994年获西北农业大学（现304永利集团官网入口）农学系农学专业学士学位，1997年获西北农业大学基础科学系生化专业硕士学位，2005年在中科院微生物所获微生物学博士学位，2005-2008年为美国普度大学生物科学系博士后，2008-2010年任中科院武汉病毒所病毒学国家重点实验室副研究员，2010年起担任304永利集团官网入口304永利集团官网入口教授、博导。
长期从事农业与环境微生物领域的前沿研究，在细菌六型分泌系统的离子转运与抗宿主天然免疫新功能研究、微生物-宿主-环境相互作用机制与调控研究、耐药菌防控新策略研究、污染物降解与生物修复、植物内共生微生物促作物抗旱抗逆机制研究等方面取得了比较突出的进展，以通讯作者在Nature Communications、PNAS、Cell Reports、PLoS Pathogens、mBio等国际著名期刊发表SCI论文50余篇。获授权专利6件。曾作为主要研究人员参加国家重大专项，973，863, 国家自然科学基金等项目的研究。兼任陕西省农业与环境微生物重点实验室副主任，中国微生物学会普通微生物专业委员会委员，中国遗传学会微生物遗传专业委员会委员，中国农业生物技术学会微生物生物技术分会理事，陕西省微生物协会理事，国际期刊《Frontiers in Cellular and Infection Microbiology》 Associate Editor，《Applied and Environmental Microbiology》编委等。
二、部分主持项目：
1. 国家自然科学基金杰出青年基金“微生物环境适应机制(31725003)”2018-2022
2. 国家重点研发计划合成生物学专项“难降解有毒污染物智能生物降解体系”课题“难降解有毒污染物智能降解体系的设计与装配” （SQ2018YFA090024-03），2019-2024
3. 陕西省“高层次人才特殊支持计划”科技创新领军人才，2019-2024
4. 国家自然科学基金面上项目“细菌VI型分泌系统转运金属离子的功能及机制研究 (31670053)”，2017-2020
5. 国家自然科学基金面上项目“谷氨酸棒杆菌对木质纤维素糖化液中酚类抑制物质的耐受机理研究(31270078)” 2013-2016
6. 国家自然科学基金面上项目“假结核耶尔森氏菌VI型分泌系统的动力学分泌机制研究(31170121)” 2012-2015
7. 科技部863“新型农业微生物肥效制剂的创制(2013AA102802)”子课题2013-2017
8. 陕西省农业攻关计划“秸秆糖化液高效利用微生物细胞工厂的构建技术研究(2014K02-12-01)” 2014-2016
三、代表性文章 (*为通讯作者)：
1. Zhang L*#, Li M#, Li Q, Chen C, Qu M, Li M, Wang Y, Shen X*. The catabolite repressor/activator, Cra, bridges a connection between carbon metabolism and host colonization in the plant drought resistance-promoting bacterium Pantoea alhagi LTYR-11Z. Appl Environ Microbiol. 2018;84(13).(Spotlight article)
2. Jinshui Lin#, Weipeng Zhang#, Juanli Cheng, Xu Yang, Kaixiang Zhu, Yao Wang, Gehong Wei, Pei-Yuan Qian, Zhao-Qing Luo and Xihui Shen*. A Pseudomonas T6SS effector recruits PQS-containing outer membrane vesicles for iron acquisition. Nat. Commun., 2017, 8:14888
3. Meiru Si, Chao Zhao, Brianne Burkinshaw, Bing Zhang, Dawei Wei, Yao Wang, Tao G. Dong* and Xihui Shen*. Manganese scavenging and oxidative stress response mediated by the type VI secretion system in Burkholderia thailandensis. PNAS, 2017, 114(11):E2233-E2242. (cited by Faculty of 1000 Prime)
4. Si M#, Wang Y#, Zhang B, Zhao C, Kang Y, Bai H, Wei D, Zhu L, Zhang L, Dong TG, Shen X*. A type VI secretion system engages a redox-regulated dual functional heme transporter for zinc acquisition. Cell Rep. 2017, 20:949-959
5. Si M, Wang T, Pan J, Lin J, Chen C, Wei Y, Lu Z, Wei G, Shen X*. Graded response of the multifunctional 2-Cys peroxiredoxin CgPrx to increasing levels of hydrogen peroxide in Corynebacterium glutamicum . Antioxid Redox Signal. 2017, 26(1):1-14.
6. Xin K#, Li M#, Chen C, Yang X, Li Q, Cheng J, Zhang L*, Shen X*. Paenibacillus qinlingensis sp. nov., an indole-3-acetic acid-producing bacterium isolated from roots of Sinopodophyllum hexandrum (Royle) Ying. Int J Syst Evol Microbiol. 2017 Apr;67(3):589-595.
7. Tietao Wang#, Meiru Si#, Yunhong Song#, Yao Wang, Fen Gao, Weipeng Zhang, Lei Zhang, Gehong Wei, Zhao-Qing Luo, Xihui Shen*. Type VI secretion system transports Zn2+ to combat multiple stresses and host immunity. PLoS Pathog. 2015, 11(7):e1005020.
8. Yunhong Song, Xiao Xiao, Changfu Li, Tietao Wang, Ruoxi Zhao, Weipeng Zhang, Lei Zhang, Yao Wang and Xihui Shen*. The dual transcriptional regulator RovM regulates the expression of AR3- and T6SS4-dependent acid survival systems in response to nutritional status in Yersinia pseudotuberculosis. Environ. Microbiol. 2015, 17(11):4631-45.
9. Meiru Si, Yixiang Xu, Tietao Wang, Mingxiu Long, Wei Ding, Can Chen, Xinmeng Guan, Yingbao Liu, Yao Wang, Xihui Shen* and Shuang-Jiang Liu. Functional characterization of a mycothiol peroxidase in Corynebacterium glutamicum that uses both mycoredoxin and thioredoxin reducing systems as proton donor for oxidative stress response. Biochem. J. 2015, 469(1):45-57.
10. Boyu Cui#, Yao Wang#, Yunhong Song, Tietao Wang, Changfu Li, Yahong Wei, Zhao-Qing Luo* and Xihui Shen*. A bioluminescence resonance energy transfer (BRET) system for measuring dynamic protein-protein interactions in bacteria. mBio 2014, 5(3):e01050-14
11. Shengjuan Xu#, Zhong Peng#, Boyu Cui, Tietao Wang, Yunhong Song, Lei Zhang, Gehong Wei, Yao Wang* and Xihui Shen*. FliS modulates FlgM activity by acting as a noncanonical chaperone to control late flagellar gene expression, motility and biofilm formation in Yersinia pseudotuberculosis . Environ. Microbiol. 2014, 16(4):1090-104 (cited by Faculty of 1000 Prime)
12. Weipeng Zhang#, Yao Wang#, Yunhong Song, Tietao Wang, Shengjuan Xu, Zhong Peng, Xiaoli Lin, Lei Zhang, Xihui Shen*. A type VI secretion system regulated by OmpR in Yersinia pseudotuberculosis functions to maintain intracellular pH homeostasis. Environ. Microbiol. 2013, 15(2):557-69.
(NewsRx报道) (Advances in Yersinia Research and Treatment 2013收录)
13. Xi-Hui Shen, Ning-Yi Zhou and Shuang-Jiang Liu. Degradation and assimilation of aromatic compounds by Corynebacterium glutamicum : another potential for applications for this bacterium? Appl. Microbiol. Biot. 2012, 95(1):77-89.
14. Li Xu#, Xihui Shen#, Andrew Bryan, Simran Banga, Michele S. Swanson, Zhao-Qing Luo. Inhibition of host vacuolar H-ATPase activity by a Legionella pneumophila effector. PLoS Pathog. 2010, 6(3): e1000822 （#共同第一作者）
15. Xihui Shen#, Simran Banga#, Yancheng Liu, Li Xu, Ping Gao, Ilya Shamovsky, Evgeny Nudler, Zhao-Qing Luo. Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response. Cell. Microbiol. 2009, 11(6):911-26.
16. Xihui Shen, Chengying Jiang, Yan Huang, Zhipei Liu, and Shuang-Jiang Liu. Functional identification of novel genes involved in the glutathione-independent gentisate pathway in Corynebacterium glutamicum . Appl. Environ. Microbiol. 2005,71(7):3442-52.
17. 沈锡辉，刘双江。谷氨酸棒杆菌代谢芳烃过程中β-酮己二酸途径中原儿茶酸支路的分子基础。中国科学C辑:生命科学 2004, 34(6) 547-554
18. 沈锡辉，刘志培，王保军，刘双江。苯酚降解菌红球菌PNAN5菌株( Rhodococcus sp . PNAN5)的分离鉴定、降解特性及其开环双加氧酶性质研究。环境科学学报 2004, 24: 482-486.
四、联系方式
通讯地址：陕西杨凌西农路22号304永利集团官网入口304永利集团官网入口
邮编：712100
联系电话：029-87092820
Email: xihuishen@nwsuaf.edu.cn
（本实验室长期招聘博士后, 待遇从优，请致函xihuishen@nwsuaf.edu.cn咨询）